Cross-linked and free-form HA, engineered as a stratified hydration matrix.
Hyaluronic acid is the dominant glycosaminoglycan of the dermis, capable of binding up to 1,000 times its weight in water. Junsui Mirai uses a stratified molecular-weight blend: high-MW HA (1,500 kDa) for surface film and plumping, mid-MW (200 – 500 kDa) for upper-dermal cushion, and oligo-HA (5 – 50 kDa) for deep-dermal CD44 receptor signaling. Cross-linked at 1.2% with proprietary BDDE-free chemistry.
HA binds water via hydrogen-bonded shell, restoring intercellular matrix volume. 1g binds up to 1L of water in dermal conditions.
Oligo-HA fragments engage CD44 receptors on keratinocytes, upregulating barrier-lipid synthesis (ceramides, AQP3) and accelerating turnover.
Hydrated HA matrix provides the 3D scaffold for fibroblast migration, collagen deposition, and elastin assembly during repair.
HA scavenges hydroxyl radicals via its glucuronic acid backbone, providing mild antioxidant defense in inflamed tissue.
Builds a tissue hydration matrix and scaffold for repair — the safest, most validated category in aesthetic medicine.
Facial volumizing — that is filler territory, a different molecule and a different intent.
FoundationalDecades of evidence
Low-MW HA (50 kDa) produced significantly greater wrinkle depth reduction (−22%) than high-MW (1,000 kDa) alone over 60 days.
Comprehensive review confirmed HA molecular-weight specific actions: HMW = anti-inflammatory, LMW = angiogenic and barrier-stimulating.
Nano-HA topical produced 40% improvement in skin hydration and 12 – 14% reduction in wrinkle depth at 8 weeks.
Each MW band acts at a different skin depth. A single-MW formula either sits on the surface (HMW only) or fails to plump (oligo only). Stratified blends address all depths.
Crosslinked HA resists hyaluronidase and provides sustained volume; free HA delivers immediate hydration and signaling. Mizu uses both.
